August 2025
Check out our new publication in microLife, titled “In vitro and in vivo selection and cost of bacteriophage resistance on natural Escherichia coli”
Bacteriophages offer a promising alternative to antibiotics. However, bacteria can develop resistance to phages, potentially limiting treatment success. This study examines how such resistance emerges and what it costs bacteria, using a clinically important E. coli strain and a tailored phage cocktail. Under nutrient-rich lab environment, phage resistance had relatively low cost. But in the gut of mice, resistant bacteria paid a high price due to changes in their cell surface. These findings highlight the importance of testing phage therapies in realistic conditions, as results can vary significantly depending on the environment.
November 2024
Highly Cited Researchers 2024
Prof. Bärbel Stecher was awarded as one of the “Highly Cited Researchers 2024” in the report released by Clarivate’s list for 2024.
June 2024
