DR. STEPHANIE HEINZLMEIR

Position: Postdoc
Room: 002
Category: Scientific staff
Phone: +49 - (0)8161 - 714265
Email: stephanie.heinzlmeir[at]tum.de

Publications

2023

  • Tröster, Alix; DiPrima, Michael; Jores, Nathalie; Kudlinzki, Denis; Sreeramulu, Sridhar; Gande, Santosh L.; Linhard, Verena; Ludig, Damian; Schug, Alexander; Saxena, Krishna; Reinecke, Maria; Heinzlmeir, Stephanie; Leisegang, Matthias S.; Wollenhaupt, Jan; Lennartz, Frank; Weiss, Manfred S.; Kuster, Bernhard; Tosato, Giovanna; Schwalbe, Harald: Optimization of the Lead Compound NVP‐BHG712 as a Colorectal Cancer Inhibitor. Chemistry – A European Journal 29 (23), 2023 mehr…

2022

  • Lier, Svenja; Sellmer, Andreas; Orben, Felix; Heinzlmeir, Stephanie; Krauß, Lukas; Schneeweis, Christian; Hassan, Zonera; Schneider, Carolin; Patricia Gloria Schäfer, Arlett; Pongratz, Herwig; Engleitner, Thomas; Öllinger, Rupert; Kuisl, Anna; Bassermann, Florian; Schlag, Christoph; Kong, Bo; Dove, Stefan; Kuster, Bernhard; Rad, Roland; Reichert, Maximilian; Wirth, Matthias; Saur, Dieter; Mahboobi, Siavosh; Schneider, Günter: A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer. Bioorganic Chemistry 119, 2022, 105505 mehr…

2021

  • Dölle, Anja; Adhikari, Bikash; Krämer, Andreas; Weckesser, Janik; Berner, Nicola; Berger, Lena-Marie; Diebold, Mathias; Szewczyk, Magdalena M.; Barsyte-Lovejoy, Dalia; Arrowsmith, Cheryl H.; Gebel, Jakob; Löhr, Frank; Dötsch, Volker; Eilers, Martin; Heinzlmeir, Stephanie; Kuster, Bernhard; Sotriffer, Christoph; Wolf, Elmar; Knapp, Stefan: Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders. Journal of Medicinal Chemistry 64 (15), 2021, 10682-10710 mehr…

2020

  • Adhikari, Bikash; Bozilovic, Jelena; Diebold, Mathias; Schwarz, Jessica Denise; Hofstetter, Julia; Schröder, Martin; Wanior, Marek; Narain, Ashwin; Vogt, Markus; Dudvarski Stankovic, Nevenka; Baluapuri, Apoorva; Schönemann, Lars; Eing, Lorenz; Bhandare, Pranjali; Kuster, Bernhard; Schlosser, Andreas; Heinzlmeir, Stephanie; Sotriffer, Christoph; Knapp, Stefan; Wolf, Elmar: PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase. Nature Chemical Biology 16 (11), 2020, 1179-1188 mehr…
  • Bian, Yangyang; Zheng, Runsheng; Bayer, Florian P.; Wong, Cassandra; Chang, Yun-Chien; Meng, Chen; Zolg, Daniel P.; Reinecke, Maria; Zecha, Jana; Wiechmann, Svenja; Heinzlmeir, Stephanie; Scherr, Johannes; Hemmer, Bernhard; Baynham, Mike; Gingras, Anne-Claude; Boychenko, Oleksandr; Kuster, Bernhard: Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC–MS/MS. Nature Communications 11 (1), 2020 mehr…
  • Frejno, Martin; Meng, Chen; Ruprecht, Benjamin; Oellerich, Thomas; Scheich, Sebastian; Kleigrewe, Karin; Drecoll, Enken; Samaras, Patroklos; Hogrebe, Alexander; Helm, Dominic; Mergner, Julia; Zecha, Jana; Heinzlmeir, Stephanie; Wilhelm, Mathias; Dorn, Julia; Kvasnicka, Hans-Michael; Serve, Hubert; Weichert, Wilko; Kuster, Bernhard: Proteome activity landscapes of tumor cell lines determine drug responses. Nature Communications 11 (1), 2020 mehr…
  • Hoermann, Bernhard; Kokot, Thomas; Helm, Dominic; Heinzlmeir, Stephanie; Chojnacki, Jeremy E.; Schubert, Thomas; Ludwig, Christina; Berteotti, Anna; Kurzawa, Nils; Kuster, Bernhard; Savitski, Mikhail M.; Köhn, Maja: Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A. Nature Communications 11 (1), 2020 mehr…
  • Li, Hui; Mercer, Ryan; Behr, Jürgen; Heinzlmeir, Stephanie; McMullen, Lynn M.; Vogel, Rudi F.; Gänzle, Michael G.: Heat and Pressure Resistance in Escherichia coli Relates to Protein Folding and Aggregation. Frontiers in Microbiology 11, 2020 mehr…
  • Montenegro, Raquel Carvalho; Howarth, Alison; Ceroni, Alessandro; Fedele, Vita; Farran, Batoul; Mesquita, Felipe Pantoja; Frejno, Martin; Berger, Benedict-Tilman; Heinzlmeir, Stephanie; Sailem, Heba Z.; Tesch, Roberta; Ebner, Daniel; Knapp, Stefan; Burbano, Rommel; Kuster, Bernhard; Müller, Susanne: Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib. Oncotarget 11 (5), 2020, 535-549 mehr…
  • Wiechmann, Svenja; Saupp, Elena; Schilling, Daniela; Heinzlmeir, Stephanie; Schneider, Günter; Schmid, Roland M.; Combs, Stephanie E.; Kuster, Bernhard; Dobiasch, Sophie: Radiosensitization by kinase inhibition revealed by phosphoproteomic analysis of pancreatic cancer cells. Molecular & Cellular Proteomics, 2020, mcp.RA120.002046 mehr…

2019

  • Mucha, Stefanie; Heinzlmeir, Stephanie; Kriechbaumer, Verena; Strickland, Benjamin; Kirchhelle, Charlotte; Choudhary, Manisha; Kowalski, Natalie; Eichmann, Ruth; Hueckelhoven, Ralph; Grill, Erwin; Kuster, Bernhard; Glawischnig, Erich: The formation of a camalexin-biosynthetic metabolon. The Plant Cell, 2019, tpc.00403.2019 mehr…
  • Reinecke, Maria; Heinzlmeir, Stephanie; Wilhelm, Mathias; Médard, Guillaume; Klaeger, Susan; Kuster, Bernhard: Kinobeads: A Chemical Proteomic Approach for Kinase Inhibitor Selectivity Profiling and Target Discovery. Target Discovery and Validation: Methods and Strategies for Drug Discovery, 2019, 97--130 mehr…
  • Reinecke, Maria; Ruprecht, Benjamin; Poser, Sandra; Wiechmann, Svenja; Wilhelm, Mathias; Heinzlmeir, Stephanie; Kuster, Bernhard; Médard, Guillaume: Chemoproteomic Selectivity Profiling of PIKK and PI3K Kinase Inhibitors. ACS Chemical Biology 14 (4), 2019, 655-664 mehr…
  • Seefried, Florian; Schmidt, Tobias; Reinecke, Maria; Heinzlmeir, Stephanie; Kuster, Bernhard; Wilhelm, Mathias: CiRCus: A Framework to Enable Classification of Complex High-Throughput Experiments. Journal of Proteome Research 18 (4), 2019, 1486-1493 mehr…

2018

  • Heinze, Simon; Zimmermann, Kerstin; Ludwig, Christina; Heinzlmeir, Stephanie; Schwarz, Wolfgang H.; Zverlov, Vladimir V.; Liebl, Wolfgang; Kornberger, Petra: Evaluation of promoter sequences for the secretory production of a Clostridium thermocellum cellulase in Paenibacillus polymyxa. Applied Microbiology and Biotechnology 102 (23), 2018, 10147-10159 mehr…
  • Tröster, Alix; Heinzlmeir, Stephanie; Berger, Benedict-Tilman; Gande, Santosh L.; Saxena, Krishna; Sreeramulu, Sridhar; Linhard, Verena; Nasiri, Amir H.; Bolte, Michael; Müller, Susanne; Kuster, Bernhard; Médard, Guillaume; Kudlinzki, Denis; Schwalbe, Harald: NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. ChemMedChem 13 (16), 2018, 1629-1633 mehr…
  • Yoon, Hongsup; Schaubeck, Monika; Lagkouvardos, Ilias; Blesl, Andreas; Heinzlmeir, Stephanie; Hahne, Hannes; Clavel, Thomas; Panda, Suchita; Ludwig, Christina; Kuster, Bernhard; Manichanh, Chaysavanh; Kump, Patrizia; Haller, Dirk; Hörmannsperger, Gabriele: Increased Pancreatic Protease Activity in Response to Antibiotics Impairs Gut Barrier and Triggers Colitis. Cellular and Molecular Gastroenterology and Hepatology 6 (3), 2018, 370-388.e3 mehr…

2017

  • Frejno, Martin; Zenezini Chiozzi, Riccardo; Wilhelm, Mathias; Koch, Heiner; Zheng, Runsheng; Klaeger, Susan; Ruprecht, Benjamin; Meng, Chen; Kramer, Karl; Jarzab, Anna; Heinzlmeir, Stephanie; Johnstone, Elaine; Domingo, Enric; Kerr, David; Jesinghaus, Moritz; Slotta‐Huspenina, Julia; Weichert, Wilko; Knapp, Stefan; Feller, Stephan M; Kuster, Bernhard: Pharmacoproteomic characterisation of human colon and rectal cancer. Molecular Systems Biology 13 (11), 2017, 951 mehr…
  • Heinzlmeir, Stephanie; Lohse, Jonas; Treiber, Tobias; Kudlinzki, Denis; Linhard, Verena; Gande, Santosh Lakshmi; Sreeramulu, Sridhar; Saxena, Krishna; Liu, Xiaofeng; Wilhelm, Mathias; Schwalbe, Harald; Kuster, Bernhard; Médard, Guillaume: Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors. ChemMedChem 12 (12), 2017, 999-1011 mehr…
  • Klaeger, Susan; Heinzlmeir, Stephanie; Wilhelm, Mathias; Polzer, Harald; Vick, Binje; Koenig, Paul-Albert; Reinecke, Maria; Ruprecht, Benjamin; Petzoldt, Svenja; Meng, Chen; Zecha, Jana; Reiter, Katrin; Qiao, Huichao; Helm, Dominic; Koch, Heiner; Schoof, Melanie; Canevari, Giulia; Casale, Elena; Depaolini, Stefania Re; Feuchtinger, Annette; Wu, Zhixiang; Schmidt, Tobias; Rueckert, Lars; Becker, Wilhelm; Huenges, Jan; Garz, Anne-Kathrin; Gohlke, Bjoern-Oliver; Zolg, Daniel Paul; Kayser, Gian; Vooder, Tonu; Preissner, Robert; Hahne, Hannes; Tõnisson, Neeme; Kramer, Karl; Götze, Katharina; Bassermann, Florian; Schlegl, Judith; Ehrlich, Hans-Christian; Aiche, Stephan; Walch, Axel; Greif, Philipp A.; Schneider, Sabine; Felder, Eduard Rudolf; Ruland, Juergen; Médard, Guillaume; Jeremias, Irmela; Spiekermann, Karsten; Kuster, Bernhard: The target landscape of clinical kinase drugs. Science 358 (6367), 2017, eaan4368 mehr…

2016

  • Gande, Santosh L.; Saxena, Krishna; Sreeramulu, Sridhar; Linhard, Verena; Kudlinzki, Denis; Heinzlmeir, Stephanie; Reichert, Andreas J.; Skerra, Arne; Kuster, Bernhard; Schwalbe, Harald: Expression and Purification of EPHA2 Tyrosine Kinase Domain for Crystallographic and NMR Studies. ChemBioChem 17 (23), 2016, 2257-2263 mehr…
  • Heinzlmeir, S. ; Kudlinzki, D. ; Sreeramulu, S. ; Klaeger, S. ; Gande, S. ; Linhard, V. ; Wilhelm, M. ; Qiao, H. ; Helm, D. ; Ruprecht, B. ; Saxena, K. ; Medard, G. ; Schwalbe, H. ; Kuster, B.: Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs. ACS Chem Biol, 2016 mehr…
  • Klaeger, Susan; Gohlke, Bjoern; Perrin, Jessica; Gupta, Vipul; Heinzlmeir, Stephanie; Helm, Dominic; Qiao, Huichao; Bergamini, Giovanna; Handa, Hiroshi; Savitski, Mikhail M; Bantscheff, Marcus; Médard, Guillaume; Preissner, Robert; Kuster, Bernhard: Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chemical Biology 11 (5), 2016, 1245-1254 mehr…
  • Ostrovskyi, Dmytro; Rumpf, Tobias; Eib, Julia; Lumbroso, Alexandre; Slynko, Inna; Klaeger, Susan; Heinzlmeir, Stephanie; Forster, Michael; Gehringer, Matthias; Pfaffenrot, Ellen; Bauer, Silke Mona; Schmidtkunz, Karin; Wenzler, Sandra; Metzger, Eric; Kuster, Bernhard; Laufer, Stefan; Schüle, Roland; Sippl, Wolfgang; Breit, Bernhard; Jung, Manfred: Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1). Future Medicinal Chemistry 8 (13), 2016, 1537-1551 mehr…
  • Slynko, Inna; Schmidtkunz, Karin; Rumpf, Tobias; Klaeger, Susan; Heinzlmeir, Stephanie; Najar, Abdulkarim; Metzger, Eric; Kuster, Bernhard; Schüle, Roland; Jung, Manfred; Sippl, Wolfgang: Identification of Highly Potent Protein Kinase C-Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing. ChemMedChem 11 (18), 2016, 2084-2094 mehr…

2015

  • Mergner, Julia; Heinzlmeir, Stephanie; Kuster, Bernhard; Schwechheimer, Claus: DENEDDYLASE1 Deconjugates NEDD8 from Non-Cullin Protein Substrates inArabidopsis thaliana. The Plant Cell 27 (3), 2015, 741-753 mehr…
  • Médard, Guillaume; Pachl, Fiona; Ruprecht, Benjamin; Klaeger, Susan; Heinzlmeir, Stephanie; Helm, Dominic; Qiao, Huichao; Ku, Xin; Wilhelm, Mathias; Kuehne, Thomas; Wu, Zhixiang; Dittmann, Antje; Hopf, Carsten; Kramer, Karl; Kuster, Bernhard: Optimized Chemical Proteomics Assay for Kinase Inhibitor Profiling. Journal of Proteome Research 14 (3), 2015, 1574-1586 mehr…
  • Ruprecht, Benjamin; Zecha, Jana; Heinzlmeir, Stephanie; Médard, Guillaume; Lemeer, Simone; Kuster, Bernhard: Evaluation of Kinase Activity Profiling Using Chemical Proteomics. ACS Chemical Biology 10 (12), 2015, 2743-2752 mehr…

2014

  • Höfener, Michael; Heinzlmeir, Stephanie; Kuster, Bernhard; Sewald, Norbert: Probing SH2-domains using Inhibitor Affinity Purification (IAP). Proteome Science 12 (1), 2014, 41 mehr…
  • Ku, Xin; Heinzlmeir, Stephanie; Helm, Dominic; Médard, Guillaume; Kuster, Bernhard: New Affinity Probe Targeting VEGF Receptors for Kinase Inhibitor Selectivity Profiling by Chemical Proteomics. Journal of Proteome Research 13 (5), 2014, 2445-2452 mehr…
  • Ku, Xin; Heinzlmeir, Stephanie; Liu, Xiaofeng; Médard, Guillaume; Kuster, Bernhard: A new chemical probe for quantitative proteomic profiling of fibroblast growth factor receptor and its inhibitors. Journal of Proteomics 96, 2014, 44-55 mehr…

2013

  • Hakenjos, J. P.; Bejai, S.; Ranftl, Q.; Behringer, C.; Vlot, A. C.; Absmanner, B.; Hammes, U.; Heinzlmeir, S.; Kuster, B.; Schwechheimer, C.: ML3 Is a NEDD8- and Ubiquitin-Modified Protein. PLANT PHYSIOLOGY 163 (1), 2013, 135-149 mehr…