Dr. Polina Prokofeva

Lechner, Severin; Sha, Shuyao; Sethiya, Jigar Paras; Szczupak, Patrycja; Dolot, Rafal; Lomada, Santosh; Sakhteman, Amirhossein; Tushaus, Johanna; Prokofeva, Polina; Krauss, Michael; Breu, Ferdinand; Vögerl, Katharina; Morgenstern, Martin; ; Hrabě de Angelis, Martin; Haucke, Volker; Wieland, Thomas; Wagner, Carston; Médard, Guillaume; Bracher, Franz; Kuster, Bernhard: Serendipitous and Systematic Chemoproteomic Discovery of MBLAC2, HINT1, and NME1-4 Inhibitors from Histone Deacetylase-Targeting Pharmacophores. ACS Chemical Biology, 2025 mehr…

Martín Moyano, Paula; Kubina, Tadeáš; Paruch, Štěpán Owen; Jarošková, Aneta; Novotný, Jan; Skočková, Veronika; Ovesná, Petra; Suchánková, Tereza; Prokofeva, Polina; Kuster, Bernhard; Šmída, Michal; Chaikuad, Apirat; Kramer, Andreas; Knapp, Stefan; Souček, Karel; Paruch, Kamil: Thieno[3,2‐b]pyridine: Attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode. Angewandte Chemie International Edition, 2024 mehr…
Popow, Johannes; Farnaby, William; Gollner, Andreas; Kofink, Christiane; Fischer, Gerhard; Wurm, Melanie; Zollman, David; Wijaya, Andre; Mischerikow, Nikolai; Hasenoehrl, Carina; Prokofeva, Polina; Arnhof, Heribert; Arce-Solano, Silvia; Bell, Sammy; Boeck, Georg; Diers, Emelyne; Frost, Aileen B.; Goodwin-Tindall, Jake; Karolyi-Oezguer, Jale; Khan, Shakil; Klawatsch, Theresa; Koegl, Manfred; Kousek, Roland; Kratochvil, Barbara; Kropatsch, Katrin; Lauber, Arnel A.; McLennan, Ross; Olt, Sabine; Peter, Daniel; Petermann, Oliver; Roessler, Vanessa; Stolt-Bergner, Peggy; Strack, Patrick; Strauss, Eva; Trainor, Nicole; Vetma, Vesna; Whitworth, Claire; Zhong, Siying; Quant, Jens; Weinstabl, Harald; Kuster, Bernhard; Ettmayer, Peter; Ciulli, Alessio: Targeting cancer with small-molecule pan-KRAS degraders. Science 385 (6715), 2024, 1338-1347 mehr…

Kücükdisli, Murat; Bel-Abed, Hassen; Cirillo, Davide; Lo, Wen-Ting; Efrém, Nina-Louisa; Horatscheck, André; Perepelittchenko, Liudmila; Prokofeva, Polina; Ehret, Theresa A. L.; Radetzki, Silke; Neuenschwander, Martin; Specker, Edgar; Médard, Guillaume; Müller, Susanne; Wilhelm, Stephanie; Kuster, Bernhard; von Kries, Jens Peter; Haucke, Volker; Nazaré, Marc: Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition. Journal of Medicinal Chemistry, 2023 mehr…
Zecha, Jana; Bayer, Florian P.; Wiechmann, Svenja; Woortman, Julia; Berner, Nicola; Müller, Julian; Schneider, Annika; Kramer, Karl; Abril-Gil, Mar; Hopf, Thomas; Reichart, Leonie; Chen, Lin; Hansen, Fynn M.; Lechner, Severin; Samaras, Patroklos; Eckert, Stephan; Lautenbacher, Ludwig; Reinecke, Maria; Hamood, Firas; Prokofeva, Polina; Vornholz, Larsen; Falcomatà, Chiara; Dorsch, Madeleine; Schröder, Ayla; Venhuizen, Anton; Wilhelm, Stephanie; Médard, Guillaume; Stoehr, Gabriele; Ruland, Jürgen; Grüner, Barbara M.; Saur, Dieter; Buchner, Maike; Ruprecht, Benjamin; Hahne, Hannes; The, Matthew; Wilhelm, Mathias; Kuster, Bernhard: Decrypting drug actions and protein modifications by dose- and time-resolved proteomics. Science 380 (6640), 2023, 93-101 mehr…

Lechner, Severin; Malgapo, Martin Ian P.; Grätz, Christian; Steimbach, Raphael R.; Baron, Agnes; Rüther, Patrick; Nadal, Simon; Stumpf, Carmen; Loos, Christina; Ku, Xin; Prokofeva, Polina; Lautenbacher, Ludwig; Heimburg, Tino; Würf, Vivian; Meng, Chen; Wilhelm, Mathias; Sippl, Wolfgang; Kleigrewe, Karin; Pauling, Josch K.; Kramer, Karl; Miller, Aubry K.; Pfaffl, Michael W.; Linder, Maurine E.; Kuster, Bernhard; Médard, Guillaume: Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nature Chemical Biology, 2022 mehr…
Lo, Wen-Ting; Belabed, Hassane; Kücükdisli, Murat; Metag, Juliane; Roske, Yvette; Prokofeva, Polina; Ohashi, Yohei; Horatscheck, André; Cirillo, Davide; Krauss, Michael; Schmied, Christopher; Neuenschwander, Martin; von Kries, Jens Peter; Médard, Guillaume; Kuster, Bernhard; Perisic, Olga; Williams, Roger L.; Daumke, Oliver; Payrastre, Bernard; Severin, Sonia; Nazaré, Marc; Haucke, Volker: Development of selective inhibitors of phosphatidylinositol 3-kinase C2α. Nature Chemical Biology, 2022 mehr…
Prokofeva, Polina; Höfer, Stefanie; Hornisch, Maximilian; Abele, Miriam; Kuster, Bernhard; Médard, Guillaume: Merits of Diazirine Photo-Immobilization for Target Profiling of Natural Products and Cofactors. ACS Chemical Biology, 2022 mehr…

DR. POLINA PROKOFEVA