As part of CRC1371, project P08 explores how inflammatory processes shape metabolic and trophic niches in the gut, influencing the composition and function of the intestinal microbiota. The focus lies on primary luminal metabolites, particularly organic acids and polyamines, and their roles in microbial sensing, uptake, and metabolic interaction. We aim to understand how these metabolites impact the fitness and proliferation of disease-associated bacteria such as Salmonella, Desulfovibrio, and Enterococcus, alongside key members of the resident microbiota. Experimental approaches include both in vitro studies and gnotobiotic mouse models, particularly those colonized with the minimal microbial consortium Oligo-MM, as well as other models of gut inflammation.

Principle Investigators:  Prof. Jung, Kirsten , Prof. Bärbel Stecher