Dr. Morgane Davezac

Glucocorticoids (GCs) are essential regulators of metabolism, immune function, and stress response. They act primarily through the glucocorticoid receptor (GR), a nuclear receptor that controls gene expression by binding to specific DNA sequences in target tissues. Despite their clinical importance, the extent to which GC signaling differs between males and females has remained poorly understood which leaves a critical gap in both basic research and therapeutic development.

A particular focus lies on the sex-specific genomic binding landscape of GR and how distinct chromatin occupancy patterns in male and female livers give rise to divergent regulation of hepatic metabolism. By identifying the molecular determinants of these differences, including sex-specific GR binding partners and co-regulators, we aim to uncover novel therapeutic targets for metabolic diseases. We combine mouse genetics, transcriptomics, epigenomics, and proteomics to address these questions, with a strong translational perspective towards sex-informed precision medicine.